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Organic chemistry synthesis of aspirin and explain mechanism of reaction
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We will prepare a chemical compound, aspirin, from its primitive compounds. We will also discuss its importance and the importance of preparing aspirin. This is a fascinating chemistry experiment because it combines organic chemistry with medical applications. Aspirin (acetylsalicylic acid) is manufactured from salicylic acid and acetic acid (or acetic anhydride) in the presence of sulfuric acid or phosphoric acid as a catalyst.Aspirin preparation (acetylsalicylic acid)
Raw materials:
Salicylic acid
Acetic anhydride
Sulfuric acid (catalyst)
distilled water
Reaction mechanism:
The reaction is esterification of the hydroxyl group of salicylic acid by acetic anhydride, resulting in the formation of an acetyl ester and the release of acetic acid as a byproduct.
1. Salicylic acid reacts with acetic anhydride.
2. Sulfuric acid breaks the bond in acetic anhydride, which helps the hydroxyl group in salicylic acid react with the acetic group.
3. Acetylsalicylic acid (aspirin) is formed with the release of acetic acid.
The importance of aspirin:
As a pain reliever and antipyretic
anti-inflammatory
It is used to prevent blood clots and heart disease.
Extra information
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Age: | Teenagers (13-17 years old) Adults (18-64 years old) Seniors (65+ years old) |
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Student level: | Intermediate Advanced |
Duration: | 60 minutes |
The class is taught in: | Arabic, English |
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