Biochemistry is a volatile subject, being a medical biochemist I make a point that my students understand the concept clearly and its relevance in modern medicine.I have been teaching Biochemistry from 2016 to medical ,nursing, and paramedical students around 1700 students in Sree Gokulam Medical College & Research Foundation,India. My classes are said to be very interesting and understandable even when the subject is hard to understand.I take real-life cases as examples to make the students understand the clinical relevance between the subject and modern medicine.